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Fifty-nine participants (HIV-/Smok- [ n = 16], HIV-/Smok+ [ n =14], HIV+/Smok- [ n = 18], and HIV+/Smok+ [ n = 11]) underwent baseline eligibility tests, positron emission tomography (PET) scanning to determine levels of a marker for neuroinflammation, and assessment of cognitive control with the reverse-translated 5-choice continuous performance test (5C-CPT), with smokers having smoked to satiety prior to testing